Nope.
As of 2022, all of these answers are broken except for the SVG one, and in that one s case you get inconsistent scaling when working with smaller sizes (Like, 24 and below...yeah, it s useful for very large headings). font-smooth is an option indeed, but it shouldn t be your first because it s actually -webkit-font-smoothing
/-moz-osx-font-smoothing
, and as the latter would imply, neither work on anything other then Mac OS X.
I have seen things such as 98.css use custom fonts that have characters constructed with boxes, which doesn t solve the problem but mitigate it. This is a VERY tedious process to do, though, and while this works fine for MS Sans Serif, it fails for more packed fonts and/or fonts at smaller sizes.
Your best option is to create images for any texts you want to be sharp. On that note, I created a program that converts PNGs to SVGs without tracing, which is a solution to let pixel perfect images be displayed properly on larger, 1440p monitors.