Update:
Since nginx version 1.15.3 you can fix this by setting the keepalive_requests option of your upstream to the same number as your php-fpm s pm.max_requests:
upstream name {
...
keepalive_requests number;
...
}
Original answer:
If you are using nginx to connect to php-fpm, one possible cause can also be having nginx fastcgi_keep_conn parameter set to on (especially if you have a low pm.max_requests setting in php-fpm):
http|server|location {
...
fastcgi_keep_conn on;
...
}
This may cause the described error every time a child process of php-fpm restarts (due to pm.max_requests being reached) while nginx is still connected to it. To test this, set pm.max_requests to a really low number (like 1) and see if you get even more of the above errors.
The fix is quite simple - just deactivate fastcgi_keep_conn:
fastcgi_keep_conn off;
Or remove the parameter completely (since the default value is off). This does mean your nginx will reconnect to php-fpm on every request, but the performance impact is negligible if you have both nginx and php-fpm on the same machine and connect via unix socket.